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KMID : 0385019990150010067
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 1 p.67 ~ p.71
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Effects of High Fat Diet in Striped Field Mice(Apodemus aprarius Pallas), KK Mice and Chinese Hamsters
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김용규/Kim, Yong Kyu
조정식/채갑용/임철주/장인석/김철규/황진희/Cho, Jung Sik/Chae, Kab Ryong/Lim, Chul Joo/Jang, In Surk/Kim, Chuel Kyu/Hwang, Jin Hee
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Abstract
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The levels of enzyme activity (α-amylase), metabolites(serum glucose, cholesterol, triglyceride) and peptide hormones (insulin, leptin) were examined in striped field mice and the diabetes model animals (KK mice and Chinese hamsters) fed moderately high fat diet for 10 weeks. Four to sis weeks old of male animal in striped field mice, KK mice and Chinese hamsters were used in this experiment and fed pelleted diet containing moderately high fat diet with 34% of energy supplied as fat. At the ending 70 days of feeding, blood was quickly collected through heart puncture and parotid gland, pancreas, liver and kidneys were removed. Serum were prepared for enzyme activity, metabolites and peptide hormone levels.
As a result of experiment, a moderately high fat diet gave rise to significant increase in blood glucose, lipid and leptin in HK mouse, known as a model animal for human diabetes(non-insulin dependent diabetes mellitus). However, a high fat diet did not induce a significant change in Chinese hamster known as a insulin dependent diabetes mellitus. Striped field mice did not also show any significant alterations in response to a high fat diet, but increased blood glucose and insulin, decreased cholesterol and triglyceride of serum compared to the diabetes model animal in basal diet. Thus, it appeared to be species-specific difference in physiological response to high fat diet and striped field mice indicated a potentially useful animal model for diabetes to study the carbohydrate mechanism in development of diabetes.
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